Mcl1-IN-7
Mcl1-IN-7 (compound 11) is a reversible covalent inhibitor of Mcl-1 with the activity of inhibiting Mcl-1. By covalently targeting the non-catalytic lysine side chain of Mcl-1, it has higher potency than non-covalent counterparts and can be used to develop Mcl-1 inhibitory compounds and study related biological phenomena.
Product Specifications
CAS Number
2012563-34-5
UNSPSC
12352005
Target
Bcl-2 Family
Type
Reference compound
Related Pathways
Apoptosis
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/mcl1-in-7.html
Smiles
O=CC1=CC(OCC2=NN(C)C(C)=C2C3=CC=CC4=C3N(C)C(C(O)=O)=C4CCCOC5=CC=CC6=C5C=CC=C6)=CC=C1B(O)O
Molecular Formula
C36H34BN3O7
Molecular Weight
631.48
References & Citations
[1]Inhibition of Mcl-1 through covalent modification of a noncatalytic lysine side chain
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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