Apoptosis inducer 18
Apoptosis inducer 18, a potent inducer of apoptosis, shows significant cytotoxicity to the breast cancer cell line MCF-7 (IC50=0.559 μM) . Apoptosis inducer 18 inhibits cell cycle progression and promotes apoptosis by binding to DNA and causing damage, and by binding to the active site of CDK-2, interfering with its kinase activity. Apoptosis inducer 18 can be used in anti-breast cancer research[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/apoptosis-inducer-18.html
Smiles
O=C1NC(SCC(NN)=O)=NC(N)=C1NC(C)=O
Molecular Formula
C8H12N6O3S
Molecular Weight
272.28
References & Citations
[1]Abd Al Moaty M N, et al. Triggering Breast Cancer Apoptosis via Cyclin-Dependent Kinase Inhibition and DNA Damage by Novel Pyrimidinone and 1, 2, 4-Triazolo [4, 3-a] pyrimidinone Derivatives[J]. ACS omega, 2024.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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