TNG348
TNG348 is an orally available allosteric inhibitor of the ubiquitin-specific protease USP1. TNG348 specifically and efficiently inhibits the activity of USP1, inhibiting its deubiquitination of proliferative PCNA and FANCD2, thereby disrupting the DNA repair process. TNG348 has inhibitory activity against breast and ovarian cancers carrying BRCA1/2 mutations and other homologous recombination defects (HRD) [1][2].
Product Specifications
CAS Number
[2839740-79-1]
UNSPSC
12352005
Target
Deubiquitinase; JNK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; MAPK/ERK Pathway
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tng348.html
Concentration
10mM
Purity
99.74
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
FC(F)(C1=CN(C)C(C2=CC=C(CN3C4=NC(C5=C(C6CC6)N=CN=C5OC)=NC=C4N(CC(F)(F)F)C3=N)C=C2)=N1)F
Molecular Formula
C27H23F6N9O
Molecular Weight
603.52
References & Citations
[J]
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
JNK1
Available Sizes
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