Temoporfin
Temoporfin (m-THPC), a reduced porphyrin, is a potent second-generation photosensitizer. Temoporfin can be used in the research of photodynamic therapy (PDT) for head and neck cancers[1][2][3].
Product Specifications
CAS Number
122341-38-2
Product Name Alternative
M-THPC; KW2345
UNSPSC
12352005
Hazard Statement
H301
Target
Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Temoporfin.html
Purity
97.34
Solubility
DMSO : 20.83 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
OC1=CC=CC(/C2=C3CCC(/C(C4=CC(O)=CC=C4)=C5C=C/C(N/5)=C(C6=CC(O)=CC=C6)/C(C=C/7)=NC7=C(C8=CC(O)=CC=C8)/C9=CC=C2N9)=N\3)=C1
Molecular Formula
C44H32N4O4
Molecular Weight
680.75
Precautions
H301
References & Citations
[2]Rovers JP, et, al. Effective treatment of liver metastases with photodynamic therapy, using the second-generation photosensitizer meta-tetra (hydroxyphenyl) chlorin (mTHPC), in a rat model. Br J Cancer. 1999 Oct;81 (4) :600-8. |[3]Reshetov V, et, al. Photodynamic therapy with conventional and PEGylated liposomal formulations of mTHPC (temoporfin) : comparison of treatment efficacy and distribution characteristics in vivo. Int J Nanomedicine. 2013;8:3817-31. |[1]Senge MO, et, al. Temoporfin (Foscan®, 5,10,15,20-tetra (m-hydroxyphenyl) chlorin) --a second-generation photosensitizer. Photochem Photobiol. 2011 Nov-Dec;87 (6) :1240-96.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
Launched
Available Sizes
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