GPX4-IN-10

GPX4-IN-10 (compound I20) is a non-covalent GPX4 inhibitor. GPX4-IN-10 induces ferroptosis and inhibits cell growth of HT1080 cells[1].

Product Specifications

UNSPSC

12352005

Target

Ferroptosis

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/gpx4-in-10.html

Smiles

CC1CCN(CC2=CC=C(NC(CN3C(C)=C(C(N(C4=CC=CC=C4)N=C5)=O)C5=C3C)=O)C=C2)CC1

Molecular Formula

C29H33N5O2

Molecular Weight

483.60

References & Citations

[1]Huang W, et al. Ferroptosis-inducing compounds synergize with docetaxel to overcome chemoresistance in docetaxel-resistant non-small cell lung cancer cells. Eur J Med Chem. 2024 Jul 10;276:116670.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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