GPX4-IN-10
GPX4-IN-10 (compound I20) is a non-covalent GPX4 inhibitor. GPX4-IN-10 induces ferroptosis and inhibits cell growth of HT1080 cells[1].
Product Specifications
UNSPSC
12352005
Target
Ferroptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/gpx4-in-10.html
Smiles
CC1CCN(CC2=CC=C(NC(CN3C(C)=C(C(N(C4=CC=CC=C4)N=C5)=O)C5=C3C)=O)C=C2)CC1
Molecular Formula
C29H33N5O2
Molecular Weight
483.60
References & Citations
[1]Huang W, et al. Ferroptosis-inducing compounds synergize with docetaxel to overcome chemoresistance in docetaxel-resistant non-small cell lung cancer cells. Eur J Med Chem. 2024 Jul 10;276:116670.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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