Vidarabine

Vidarabine (Ara-A) an antiviral agent which is active against herpes simplex and varicella zoster viruses[1][2]. Vidarabine has IC50s of 9.3 μg/ml for HSV-1 and 11.3 μg/ml for HSV-2[2]. Vidarabine also has anti-orthopoxvirus activity[3].

Product Specifications

CAS Number

[5536-17-4]

Product Name Alternative

Ara-A; Adenine Arabinoside; 9-β-D-Arabinofuranosyladenine

UNSPSC

12352005

Hazard Statement

H361

Target

Antibiotic; HSV; Nucleoside Antimetabolite/Analog; Orthopoxvirus

Type

Natural Products

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/Vidarabine.html

Concentration

10mM

Purity

99.36

Solubility

DMSO : 50 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL

Smiles

OC[C@@H]1[C@@H](O)[C@H](O)[C@H](N2C3=NC=NC(N)=C3N=C2)O1

Molecular Formula

C10H13N5O4

Molecular Weight

267.25

Precautions

H361

References & Citations

[1]Whitley, R., et al., Vidarabine: a preliminary review of its pharmacological properties and therapeutic use. Drugs, 1980. 20 (4) : p. 267-82.|[2]Suzuki M, et al. Synergistic antiviral activity of acyclovir and vidarabine against herpes simplex virus types 1 and 2 and varicella-zoster virus. Antiviral Res. 2006;72 (2) :157-161.|[3]Donald F Smee, et al. A review of compounds exhibiting anti-orthopoxvirus activity in animal models. Antiviral Res. 2003 Jan;57 (1-2) :41-52.