1-Alaninechlamydocin

1-Alaninechlamydocin, a cyclic tetrapeptide, is a potent HDAC inhibitor (IC50=6.4 nM) . 1-Alaninechlamydocin induces G2/M cell cycle arrest and apoptosis in MIA PaCa-2 cells[1].

Product Specifications

CAS Number

[141446-96-0]

UNSPSC

12352209

Target

Apoptosis; HDAC

Type

Peptides

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/1-alaninechlamydocin.html

Solubility

10 mM in DMSO

Smiles

O=C([C@@H](NC([C@@H]1C)=O)CC2=CC=CC=C2)N(CCC3)[C@@]3([H])C(N[C@H](C(N1)=O)CCCCCC([C@@H]4CO4)=O)=O

Molecular Formula

C27H36N4O6

Molecular Weight

512.60

References & Citations

[1]Du L, et al. A potent HDAC inhibitor, 1-alaninechlamydocin, from a Tolypocladium sp. induces G2/M cell cycle arrest and apoptosis in MIA PaCa-2 cells. J Nat Prod. 2014;77 (7) :1753-1757.