Fulvestrant-3-boronic acid
Fulvestrant-3-boronic acid is an orally active ERα inhibitor, which binds to ERα competitively (IC50 = 4.1 nM) and effectively degrades ERα in breast cancer cells[1].
Product Specifications
CAS Number
[1853279-29-4]
Product Name Alternative
ZB716
UNSPSC
12352005
Hazard Statement
H360, H362, H400, H410
Target
Estrogen Receptor/ERR
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/fulvestrant-3-boronic-acid.html
Purity
99.7
Smiles
FC(F)(F)C(F)(F)CCCS(CCCCCCCCC[C@H]1[C@]2([H])[C@@](CC[C@]3([C@@]2([H])CC[C@@H]3O)C)([H])C4=CC=C(B(O)O)C=C4C1)=O
Molecular Formula
C32H48BF5O4S
Molecular Weight
634.59
Precautions
H360, H362, H400, H410
References & Citations
[1]Liu J, et al. Fulvestrant-3 Boronic Acid (ZB716) : An Orally Bioavailable Selective Estrogen Receptor Downregulator (SERD) . J Med Chem. 2016 Sep 8;59 (17) :8134-40.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
Curated Selection
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