Antibacterial agent 237

Antibacterial agent 237 (compound Ru-8) is a bacteriostatic agent for Staphylococcus aureus, with MIC of 0.78-1.56 μg/mL. Antibacterial agent 237 destroys bacterial cell membranes, changes their permeability, and induces bacteria to produce Reactive Oxygen Species, leading to bacterial death without causing drug resistance. Antibacterial agent 237 has low hemolytic toxicity to rabbit red blood cells and Raw 264.7 cells, and has significant antibacterial effects against Staphylococcus aureus in mouse skin wound infection models and Bacillus major larvae infection models[1].

Product Specifications

CAS Number

[9007-83-4]

UNSPSC

12352005

Target

Bacterial; Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/antibacterial-agent-237.html

Smiles

CC(C)(C)C(C=C1)=CC(C2=CC(C(C)(C)C)=CC=[N]23)=[N]1[Ru+2]435([N]6=CC=CC7=C6C([N]5=CC=C8)=C8C9=C7NC(C%10=CC=C(SC%11=NC(C%12=CC=[N+](CC)C=C%12)=CS%11)C=C%10)=N9)[N]%13=CC=C(C(C)(C)C)C=C%13C%14=[N]4C=CC(C(C)(C)C)=C%14.[Cl-].[Cl-].[Cl-]

Molecular Formula

C65H69Cl3N10RuS2

Molecular Weight

1261.87

References & Citations

[1]Wei Deng , et al. Discovery of quaternized pyridine-thiazole-ruthenium complexes as potent anti-Staphylococcus aureus agents. Eur J Med Chem. 2024 Nov 5:277:116712.