Phomopsinamine A
Phomopsinamine A is a derivative of Phomopsin A. Phomopsinamine A is an inhibitor for tubulin polymerization with IC50 of 0.53 μM. Phomopsinamine A inhibits the binding of Vinblastine (HY-13780) to tubulin (IC50 =0.56 μM), promotes the the binding of Colchicine (HY-16569) to tubulin (IC50 =0.32 μM).
Product Specifications
CAS Number
89085-54-1
UNSPSC
12352209
Target
Microtubule/Tubulin
Type
Peptides
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/phomopsinamine-a.html
Smiles
ClC1=CC([C@@H]([C@@H]2NC)O)=CC(O[C@@](C)([C@@]([H])(C(N3[C@@]([H])(C=CC3)C(N/C(C(N)=O)=C(C)/CC)=O)=O)NC([C@@H](NC2=O)C(C)=C)=O)CC)=C1O
Molecular Formula
C32H43ClN6O8
Molecular Weight
675.17
References & Citations
[1]Lacey E, et al., Interaction of phomopsin A and related compounds with purified sheep brain tubulin. Biochem Pharmacol. 1987 Jul 1;36 (13) :2133-8.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Frequently Asked Questions
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