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5-OMe-UDP

5-OMe-UDP (5-methoxyuridine 5'-trihydrogen diphosphate) is a P2Y6 receptor agonist (EC50=0.08 μM) . 5-OMe-UDP activates the P2Y6 receptor by binding to it, which triggers signaling pathways within the cell. This activation can lead to an increase in intracellular calcium ion concentration, which in turn regulates cellular function. The methoxy groups of 5-OMe-UDP provide additional activity and selectivity, contributing to the binding of 5-OMe-UDP to the P2Y6 receptor. 5-OMe-UDP can be used to study diseases related to P2Y6 receptor function, such as diabetes, inflammatory bowel disease, Alzheimer's disease, etc[1].

Product Specifications

CAS Number

1207530-98-0

Product Name Alternative

5-Methoxyuridine 5'- (trihydrogen diphosphate)

UNSPSC

12352005

Target

P2Y Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/5-ome-udp.html

Smiles

O=C(N1)N([C@@H]2O[C@H](COP(O)(OP(O)(O)=O)=O)[C@@H](O)[C@H]2O)C=C(OC)C1=O

Molecular Formula

C10H16N2O13P2

Molecular Weight

434.19

References & Citations

[1]Ginsburg-Shmuel T, et al. UDP made a highly promising stable, potent, and selective P2Y6-receptor agonist upon introduction of a boranophosphate moiety[J]. Bioorganic & medicinal chemistry, 2012, 20 (18) : 5483-5495.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

P2Y6 Receptor

Frequently Asked Questions

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