Retrorsine

Retrorsine is a naturally occurring toxic pyrrolizidine alkaloid. Retrorsine can bind with DNA and inhibits the proliferative capacity of hepatocytes. Retrorsine can be used for the research of hepatocellular injury[1][2].

Product Specifications

CAS Number

[480-54-6]

UNSPSC

12352005

Hazard Statement

H300

Target

Others

Type

Natural Products

Related Pathways

Others

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/retrorsine.html

Purity

99.91

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(O[C@]1([H])CCN2[C@]1([H])C(COC([C@](CO)(O)[C@H](C)C/3)=O)=CC2)C3=C/C

Molecular Formula

C18H25NO6

Molecular Weight

351.39

Precautions

H300

References & Citations

[1]F J Cubero, et al. Hepatic proliferation in Gunn rats transplanted with hepatocytes: effect of retrorsine and tri-iodothyronine. Cell Prolif. 2005 Jun;38 (3) :137-46.|[2]Yao Lu, et al. Establishment of a novel CYP3A4-transduced human hepatic sinusoidal endothelial cell model and its application in screening hepatotoxicity of pyrrolizidine alkaloids. J Environ Sci Health C Toxicol Carcinog. 2020;38 (2) :169-185.|[3]S Laconi, et al. Liver regeneration in response to partial hepatectomy in rats treated with retrorsine: a kinetic study. J Hepatol. 1999 Dec;31 (6) :1069-74.|[4]Christian Picard, et al. Retrorsine: a kinetic study of its influence on rat liver regeneration in the portal branch ligation model. J Hepatol. 2003 Jul;39 (1) :99-105.