Vigabatrin (hydrochloride)

Vigabatrin hydrochloride (γ-Vinyl-GABA hydrochloride), a inhibitory neurotransmitter GABA vinyl-derivative, is an orally active and irreversible GABA transaminase inhibitor. Vigabatrin hydrochloride is an antiepileptic agent, which acts by increasing GABA levels in the brain by inhibiting the catabolism of GABA by GABA transaminase[1][2][3].

Product Specifications

CAS Number

[1391054-02-6]

Product Name Alternative

γ-Vinyl-GABA (hydrochloride)

UNSPSC

12352211

Hazard Statement

H302, H312, H332

Target

GABA Receptor

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Vigabatrin-Hydrochloride.html

Purity

98.0

Solubility

DMSO : 27.5 mg/mL (ultrasonic; warming) |H2O : 33.33 mg/mL (ultrasonic)

Smiles

C=CC(N)CCC(O)=O.Cl

Molecular Formula

C6H12ClNO2

Molecular Weight

165.62

Precautions

H302, H312, H332

References & Citations

[1]Broeer, et al. Vigabatrin for focal drug delivery in epilepsy: Bilateral microinfusion into the subthalamic nucleus is more effective than intranigral or systemic administration in a rat seizure model. Neurobiology of Disease (2012), 46 (2), 362-376.|[2]Gaily, Eija Vigabatrin monotherapy for infantile spasms. Expert Review of Neurotherapeutics (2012), 12 (3), 275-286.|[3]Jakob Plum, et al. The anti-epileptic drug substance vigabatrin inhibits taurine transport in intestinal and renal cell culture models. Int J Pharm. 2014 Oct 1;473 (1-2) :395-7.