Cyy-272
Cyy-272 is an orally active JNK inhibitor with IC50 values of 1.25 μM for JNK1, 1.07 μM for JNK2, and 1.24 μM for JNK3. Cyy-272 exerts anti-inflammatory effects by inhibiting JNK phosphorylation, thereby alleviating acute lung injury (ALI) induced by lipopolysaccharide (LPS, HY-D1056). Additionally, Cyy-272 significantly reduces inflammation in cardiomyocytes and cardiac tissue induced by high lipid concentrations, further mitigating cardiac hypertrophy, fibrosis, and apoptosis. Cyy-272 can be used in the study of obese cardiomyopathy[1].
Product Specifications
CAS Number
2644673-01-6
UNSPSC
12352005
Target
Apoptosis; JNK
Type
Reference compound
Related Pathways
Apoptosis; MAPK/ERK Pathway
Field of Research
Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/cyy-272.html
Smiles
CC1=C(N=C(N=C1)NC2=CC=C(C=C2)N3CCC(F)(CC3)F)NC4=CC=C5C=NNC5=C4
Molecular Formula
C23H23F2N7
Molecular Weight
435.47
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
JNK1; JNK2; JNK3
Frequently Asked Questions
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