Bisoprolol (hemifumarate)

Bisoprolol hemifumarate is a potent, selective and orally active β1-adrenergic receptor blocker with little activity on β2-receptor. Bisoprolol hemifumarate has the potential for hypertension, coronary artery disease and stable ventricular dysfunction research[1][2].

Product Specifications

CAS Number

[104344-23-2]

UNSPSC

12352005

Hazard Statement

H302, H361, H373

Target

Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Endocrinology; Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/__plusmn__-bisoprolol-hemifumarate.html

Purity

99.84

Solubility

DMSO : ≥ 50 mg/mL|H2O : 20 mg/mL (ultrasonic)

Smiles

OC(CNC(C)C)COC1=CC=C(COCCOC(C)C)C=C1.OC(/C=C/C(O)=O)=O

Molecular Formula

C18H31NO4.1/2C4H4O4

Molecular Weight

383.48

Precautions

H302, H361, H373

References & Citations

[1]Jillian G Baker, et al. The selectivity of beta-adrenoceptor antagonists at the human beta1, beta2 and beta3 adrenoceptors. Br J Pharmacol. 2005 Feb;144 (3) :317-22. |[2]Jing Wang, et al. Bisoprolol, a β 1 antagonist, protects myocardial cells from ischemia-reperfusion injury via PI3K/AKT/GSK3β pathway. Fundam Clin Pharmacol. 2020 Dec;34 (6) :708-720. |[3]Hong Yang, et al. Bisoprolol reverses epinephrine-mediated inhibition of cell emigration through increases in the expression of β-arrestin 2 and CCR7 and PI3K phosphorylation, in dendritic cells loaded with cholesterol. Thromb Res. 2013 Mar;131 (3) :230-7. |[4]Jinhua Liu, et al. Protective Effects of Bisoprolol Against Cadmium-induced Myocardial Toxicity Through Inhibition of Oxidative Stress and NF-κΒ Signalling in Rats. J Vet Res. 2021 Oct 20;65 (4) :505-511. |[5]Yajuan Ni, et al. Bisoprolol reversed small conductance calcium-activated potassium channel (SK) remodeling in a volume-overload rat model. Mol Cell Biochem. 2013 Dec;384 (1-2) :95-103.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Launched

Isoform

β adrenergic receptor

Citation 01

Am J Respir Cell Mol Biol. 2023 Aug;69 (2) :230-241.|Cell Rep. 2024 May 31;43 (6) :114302.|Int J Mol Sci. 2023 Aug 9;24 (16) :12609.|Mol Neurobiol. 2019 Jan;56 (1) :367-377. |ACS Omega. 2022 Aug 8;7 (32) :27950-27958.|J Pharm Biomed Anal. 2021 Feb 20:195:113870.

Available Sizes

Curated Selection

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