Fenobam (hydrate)
Fenobam hydrate is a selective and orally active mGluR5 antagonist (IC50=84 nM) that can penetrate the blood-brain barrier. Fenobam hydrate shows the Kd values of 54 nM and 31 nM on rat and human recombinant mGlu5 receptors, respectively. Fenobam hydrate has anxiolytic activity, inhibits self-administration behavior in rat, and induces apoptosis in cancer cells. Fenobam hydrate can be used for research on neurological diseases, cancer and drug addiction[1][2][3].
Product Specifications
CAS Number
63540-28-3
UNSPSC
12352005
Target
Apoptosis; mGluR
Type
Reference compound
Related Pathways
Apoptosis; GPCR/G Protein; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/fenobam-hydrate.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=NC(CN1C)=O)NC2=CC=CC(Cl)=C2.O
Molecular Formula
C11H13ClN4O3
Molecular Weight
284.70
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
MGluR5
Frequently Asked Questions
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