PF-05214030
PF-05214030 is a TRPV4 antagonist (IC50: 4 and 27nM for hTRPV4 and rTRPV4 respectively) . PF-05214030 reverses the reduction in bladder capacity caused by intravesical infusion of a TRPV4 agonist[1][2].
Product Specifications
CAS Number
1669444-50-1
UNSPSC
12352005
Target
TRP Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/pf-05214030.html
Purity
99.81
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
N#CC1=CC=C(C=C1F)OCC2(CN(S(=O)(C3=CC=C(C=C3Cl)Cl)=O)C2)O
Molecular Formula
C17H13Cl2FN2O4S
Molecular Weight
431.27
References & Citations
[1]Jiang Y, et al. Targeting extracellular matrix stiffness and mechanotransducers to improve cancer therapy. J Hematol Oncol. 2022 Mar 24;15 (1) :34.|[2]Sarah Skerratt, et al. The Discovery and Optimisation of a Highly Selective Series of TRPV4 Antagonists.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TRPV4
Available Sizes
Frequently Asked Questions
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