SIRT3-IN-1
SIRT3-IN-1 (compound 17f) is a SIRT3 inhibitor, with IC50 of 0.043 μM. SIRT3-IN-1 can be used in the research of acute leukemia (AML) [1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Sirtuin
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sirt3-in-1.html
Purity
98.47
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CC2=NC=NC(N([C@H](CC3)C4)[C@@H]3CN4C(NC5=CC=C(C(F)(F)F)C=C5)=O)=C2S1)N
Molecular Formula
C21H19F3N6O2S
Molecular Weight
476.47
References & Citations
[1]Yang X, et al. Design, synthesis and biological evaluation of novel SIRT3 inhibitors targeting both NAD+ and substrate binding sites for the treatment of acute myeloid leukemia. Eur J Med Chem. 2024 Oct 5;276:116689.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
SIRT3
Available Sizes
Curated Selection
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