FOXO4-DRI (acetate)

FOXO4-DRI acetate is a cell-permeable peptide antagonist that blocks the interaction of FOXO4 and p53. FOXO4-DRI acetate is a senolytic peptide that induces apoptosis of senescent cells[1].

Product Specifications

UNSPSC

12352209

Target

Apoptosis; MDM-2/p53

Type

Peptides

Related Pathways

Apoptosis

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/foxo4-dri-acetate.html

Solubility

H2O

Smiles

[D-(LTLRKEPASEIAQSILEAYSQNGWANRRSGGKRPPPRRRQRRKKRG)(acetatesalt)]

Molecular Formula

C228H388N86O64.0.145C2H4O2

Molecular Weight

5366.77

References & Citations

[1]Zhang C, et al. FOXO4-DRI alleviates age-related testosterone secretion insufficiency by targeting senescent Leydig cells in aged mice. Aging (Albany NY) . 2020 Jan 20;12 (2) :1272-1284.|[2]Huang Y, et al. Senolytic Peptide FOXO4-DRI Selectively Removes Senescent Cells From in vitro Expanded Human Chondrocytes. Front Bioeng Biotechnol. 2021 Apr 29;9:677576.