HP211206

HP211206 is a SARS-CoV-2 main protease (Mpro) PROTAC degrader. HP211206 effectively degrades SARS-CoV-2 Mpro and its drug-resistant mutants. HP211206 has an IC50 of 181.9 nM and a DC50 of 621 nM for Mpro. HP211206 has antiviral activity. (Pink: H117 (HY-170599) ; Black: linker (HY-B0236) ; Blue: E3 ligase ligand (HY-41547) ) [1].

Product Specifications

UNSPSC

12352005

Target

PROTACs; SARS-CoV; Virus Protease

Type

Reference compound

Related Pathways

Anti-infection; PROTAC

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/hp211206.html

Purity

99.94

Smiles

O=C(CCC1N2C(C(C(NCCCCCC(N(C)[C@@H](C)C(N[C@@H](C(C)(C)C)C(N3[C@H](C(N[C@H](C#N)C[C@H]4C(NCC4)=O)=O)C[C@@H](OC(F)F)C3)=O)=O)=O)=CC=C5)=C5C2=O)=O)NC1=O

Molecular Formula

C42H55F2N9O10

Molecular Weight

883.94

References & Citations

[1]Sang X, et al. A Chemical Strategy for the Degradation of the Main Protease of SARS-CoV-2 in Cells. J Am Chem Soc. 2023 Dec 20;145 (50) :27248-27253.