UniPR1454
UniPR1454 targets EphA2 receptor, inhibits the EphA2-ephrin A1 interaction with an IC50 of 2.6 μM. UniPR1454 inhibits the proliferation of glioblastoma cell U251[1].
Product Specifications
UNSPSC
12352005
Target
Ephrin Receptor
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/unipr1454.html
Smiles
C[C@]12[C@]([H])([C@]3([C@@]([H])([C@]4(C)C(C[C@@H](O)CC4)=CC3)CC2)[H])CC[C@@]1([C@@H](CCC(N[C@H](CC(O)=O)CC5=CN(C6=C5C=CC=C6)S(=O)(C7=CC=C(C=C7)C(F)(F)F)=O)=O)C)[H]
Molecular Formula
C43H53F3N2O6S
Molecular Weight
782.95
References & Citations
[1]Guidetti L, et al., Discovery of a new 1- (phenylsulfonyl) -1H-indole derivative targeting the EphA2 receptor with antiproliferative activity on U251 glioblastoma cell line. Eur J Med Chem. 2024 Jul 15;276:116681.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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