SOD1 (147-153) human

SOD1 (147-153) human is a peptide fragment of Cu/Zn superoxide dismutase (SOD1) with a high propensity to form amyloid fibrils. SOD1 (147-153) human may trigger the aggregation of full-length SOD1 and is a common molecular determinant of familial amyotrophic lateral sclerosis (fALS) and sporadic amyotrophic lateral sclerosis (sALS) [1].

Product Specifications

CAS Number

[2760733-01-3]

UNSPSC

12352209

Target

Amyloid-β

Type

Peptides

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/sod1-147-153-human.html

Smiles

O=C(N[C@@H](C(C)C)C(N[C@@H]([C@@H](C)CC)C(NCC(N[C@@H]([C@@H](C)CC)C(N[C@@H](C)C(N[C@@H](CCC(N)=O)C(O)=O)=O)=O)=O)=O)=O)CN

Molecular Formula

C29H52N8O9

Molecular Weight

656.77

References & Citations

[1]Ivanova, et al. "Aggregation-triggering segments of SOD1 fibril formation support a common pathway for familial and sporadic ALS." Proceedings of the National Academy of Sciences 111.1 (2014) : 197-201.