Human PCSK9 Protein, C-terminal domain truncated, His Tag

PCSK9 [Biotinylated] : LDL R Inhibitor Screening ELISA Assay Pair is based on a competition-ELISA method, is used to screening for inhibitors of human PCSK9 binding to human LDL R. The kit is designed to provide a reliable solution for the screening of antibodies and small molecule inhibitors in the early stages, as well as QC release, to help researchers quickly screen and validate drugs, effectively improving research and development efficiency. It can also be used as a universal detection tool to identify the ability of human PCSK9 to bind to human LDL R.

Product Specifications

Background

Specifications

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 13.8 kDa & 33.5 kDa. The protein migrates as 15 kDa and 33 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation. This protein variant lacks the C-terminal domain (CRD), which is essential for its LDLR binding and degradation functions.

Accession Number

Q8NBP7-1

Expression Region

Gln 31 -His 449

Host

HEK293

Target

PCSK9

Conjugation

Unconjugated

Tag

C-10xHis

Source

Human

Stability

-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.