Aminoacyl tRNA synthetase-IN-3
Product Specifications
UNSPSC Description
Aminoacyl tRNA synthetase-IN-3 (compound 36K3) is an inhibitor of lysine tRNA synthetase (PfLysRS) from Plasmodium falciparum (IC50=59.2 nM), which inhibits the activity of PfLysRS by occupying the ATP binding site and L-lysine binding site of PfLysRS. Aminoacyl tRNA synthetase-IN-3 can be used in the development of antimalarial drugs[1].
Target Antigen
Aminoacyl-tRNA Synthetase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/aminoacyl-trna-synthetase-in-3.html
Smiles
COC1=C(NC2=NC=NC(NC3=CC=CC=C3S(CCCNC([C@H](CCCCN)N)=O)(=O)=O)=N2)C=C(OC)C=C1
Molecular Weight
572.68
References & Citations
[1]Zhou J, et al. Structure-guided conversion from an anaplastic lymphoma kinase inhibitor into Plasmodium lysyl-tRNA synthetase selective inhibitors[J]. Communications Biology, 2024, 7(1): 742.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-161800/Aminoacyl-tRNA-synthetase-IN-3-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-161800/
Clinical Information
No Development Reported
Curated Selection
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