Aminoacyl tRNA synthetase-IN-3
Selected Variant
HY-161800
Size: 1 Each
Aminoacyl tRNA synthetase-IN-3 (compound 36K3) is an inhibitor of lysine tRNA synthetase (PfLysRS) from Plasmodium falciparum (IC50=59.2 nM), which inhibits the activity of PfLysRS by occupying the ATP binding site and L-lysine binding site of PfLysRS. Aminoacyl tRNA synthetase-IN-3 can be used in the development of antimalarial drugs[1].
Product Specifications
UNSPSC
12352005
Target
Aminoacyl-tRNA Synthetase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/aminoacyl-trna-synthetase-in-3.html
Smiles
COC1=C(NC2=NC=NC(NC3=CC=CC=C3S(CCCNC([C@H](CCCCN)N)=O)(=O)=O)=N2)C=C(OC)C=C1
Molecular Formula
C26H36N8O5S
Molecular Weight
572.68
References & Citations
[1]Zhou J, et al. Structure-guided conversion from an anaplastic lymphoma kinase inhibitor into Plasmodium lysyl-tRNA synthetase selective inhibitors[J]. Communications Biology, 2024, 7 (1) : 742.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Price
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