Akt/mTOR-IN-1
Akt/mTOR-IN-1 (Compound 8r) is an AKT/mTOR signaling pathway inhibitor exhibiting an IC50 value of 0.8 µM with anticancer activity. Akt/mTOR-IN-1 can decrease the expression of Caspase 3 and increase the expression of the autophagic protein Cyclin B1, thereby inducing cell autophagy and apoptosis. Akt/mTOR-IN-1 can be used in research related to non-small cell lung cancer (NSCLC) [1].
Product Specifications
UNSPSC
12352005
Target
Akt; Caspase; CDK; mTOR
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; PI3K/Akt/mTOR
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/akt-mtor-in-1.html
Smiles
O=C1NC(C2(O)C=CC(C=C2)=O)=C(C3=CC=C(C(F)(F)F)C=C3)C4=C1N(CC5=CC=CC=C5)C6=C4C=CC=C6
Molecular Formula
C31H21F3N2O3
Molecular Weight
526.51
References & Citations
[1]Lv L, et al. Design, synthesis and anticancer activity of β-carboline based pseudo-natural products by inhibiting AKT/mTOR signaling pathway. Bioorg Chem. 2024 Jul 15;151:107648.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Caspase 3
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC940177-100 1x 100 µL
CD50 (ICAM-3) (101-1D2), CF594 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC140017-100 1x 100 µL
Ep-CAM / CD326 (VU-1D9), CF514 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC880257-500 1x 500 µL
Cytokeratin, HMW (AE-3), CF488A conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC941707-100 1x 100 µL
Human IgG (Immunoglobulin Gamma Heavy Chain) (B-Cell Marker) (IG1707R), CF594 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC680715-100 1x 100 µL
Thymidylate Synthase (TMS715), CF568 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC941660-500 1x 500 µL
Cytokeratin 1 (Suprabasal Keratinocyte Marker) (LHK1), CF594 conjugate, 0.1mg/mL
Sign In for Pricing
View Details