Akt/mTOR-IN-1

Akt/mTOR-IN-1 (Compound 8r) is an AKT/mTOR signaling pathway inhibitor exhibiting an IC50 value of 0.8 µM with anticancer activity. Akt/mTOR-IN-1 can decrease the expression of Caspase 3 and increase the expression of the autophagic protein Cyclin B1, thereby inducing cell autophagy and apoptosis. Akt/mTOR-IN-1 can be used in research related to non-small cell lung cancer (NSCLC) [1].

Product Specifications

UNSPSC

12352005

Target

Akt; Caspase; CDK; mTOR

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; PI3K/Akt/mTOR

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/akt-mtor-in-1.html

Smiles

O=C1NC(C2(O)C=CC(C=C2)=O)=C(C3=CC=C(C(F)(F)F)C=C3)C4=C1N(CC5=CC=CC=C5)C6=C4C=CC=C6

Molecular Formula

C31H21F3N2O3

Molecular Weight

526.51

References & Citations

[1]Lv L, et al. Design, synthesis and anticancer activity of β-carboline based pseudo-natural products by inhibiting AKT/mTOR signaling pathway. Bioorg Chem. 2024 Jul 15;151:107648.