WB436B
WB436B is a highly selective STAT3 inhibitor. WB436B can selectively inhibit STAT3-Tyr705 phosphorylation and the expression of STAT3 target genes, showing cytotoxic effects on pancreatic cancer cells and inducing apoptosis. WB436B can suppress tumor growth and metastasis in pancreatic cancer mouse models, extending the survival of tumor-bearing mice[1].
Product Specifications
CAS Number
2248552-84-1
UNSPSC
12352005
Target
Apoptosis; STAT
Type
Reference compound
Related Pathways
Apoptosis; JAK/STAT Signaling; Stem Cell/Wnt
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/wb436b.html
Purity
99.93
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
COC1=C(NC(N2CC(SC(NC(C3=CN(C)N=C3)=O)=C4C#N)=C4CC2)=O)C=CC=C1
Molecular Formula
C21H20N6O3S
Molecular Weight
436.49
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
STAT3
Available Sizes
Frequently Asked Questions
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