WX8
WX8 (Ro 91-4714) is an ATP-competitive PIKFYVE inhibitor, with Kd values of 0.9 nM and 340 nM for PIKFYVE and PIP4K2C, respectively. WX8 (Ro 91-4714) inhibits lysosomal fission without effecting homotypic lysosomal fusion. WX8 (Ro 91-4714) is used in the research of autophagy-dependent cancer[1].
Product Specifications
CAS Number
232935-92-1
Product Name Alternative
Ro 91-4714
UNSPSC
12352005
Target
PIKfyve
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/wx8.html
Purity
99.43
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C1(/C=N/NC2=NC(NC3=CC=CC=C3)=NC(N4CCOCC4)=N2)=CNC5=C1C=CC=C5
Molecular Formula
C22H22N8O
Molecular Weight
414.46
References & Citations
[1]Ajit Roy, et al. Selective Termination of Autophagy-Dependent Cancers. Cells. 2024 Jun 25;13 (13) :1096.|[2]Gaurav Sharma, et al. A family of PIKFYVE inhibitors with therapeutic potential against autophagy-dependent cancer cells disrupt multiple events in lysosome homeostasis. Autophagy. 2019 Oct;15 (10) :1694-1718.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
372158-01 20 µg
ADIPOQ, Recombinant, Bovine, aa18-240, His-SUMO-Tag (Adiponectin)
Sign In for Pricing
View Details 372158-02 100 µg
ADIPOQ, Recombinant, Bovine, aa18-240, His-SUMO-Tag (Adiponectin)
Sign In for Pricing
View Details ![HEPC (HAMP) (25-85) Mouse Monoclonal Antibody [Clone ID: 1F9]](https://cdn.genprice.uk/products/937/68dd189c061270361e8fc9af/imageurl/am21007pu-n.webp)
AM21007PU-N 50 µg
HEPC (HAMP) (25-85) Mouse Monoclonal Antibody [Clone ID: 1F9]
Sign In for Pricing
View Details 
MR215473L3V 200 µL
Adgrb1 (NM_174991) Mouse Tagged ORF Clone Lentiviral Particle
Sign In for Pricing
View Details