Human Renal Proximal Tubular Epithelial Cells

Renal proximal tubular epithelial cells (PTEpiC) play a crucial role in renal function. They reabsorb nearly all of the glucose and amino acids in the glomerular filtrate, while allowing other substances of no nutritional value to be excreted in the urine. They are also a major site of injury in a variety of congenital, metabolic, and inflammatory diseases. PTEpiC can produce inflammatory mediators such as cytokines and chemokines and actively participate in acute inflammatory processes by affecting and directing leukocyte chemotaxis via the production of IL-8. PTEpiC express IL-2R alpha and MHC class II antigens during inflammation after renal transplantation or in crescentic glomerulonephritis indicating the capacity to participate in the pathogenesis of immune renal injury. To be able to study the relationship between tubular cells and a variety of renal diseases, the PTEpiC culture provides a useful in vitro model.HRPTEpiC from AcceGen Research Laboratories are isolated from human kidney. HRPTEpiC are cryopreserved at passage one and delivered frozen. Each vial contains >5×10^5 cells in 1 ml volume. HRPTEpiC are characterized by immunofluorescent method with antibodies to cytokeratin-18, -19 and vimentin. HRPTEpiC are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi. HRPTEpiC are guaranteed to further expand for 15 population doublings in the condition provided by AcceGen Research Laboratories.