Human Choroid Plexus Endothelial Cells

The choroid plexus plays a wide range of roles in brain development, maturation, aging process, endocrine regulation, and pathogenesis of certain neurodegenerative diseases. The choroid plexuses consist of a single layer of epithelial cells enclosing a vascular core that together form the blood-cerebrospinal fluid barrier. The choroidal capillary is a single layer of endothelial cells interrupted by "pores" which exhibit a diaphragm between the lumen and the interstitial space. Study shows that choroid plexus endothelial cells express high Glut1 glucose transporter. The high glucose transport densities in choroids plexus endothelial cells is consistent with the suggestion that choroids epithelial and endothelial cells provide a metabolic work capability for maintaining ionic gradients and secretory functions across the blood-cerebrospinal fluid barriers.HCPEC from AcceGen Research Laboratories are isolated from human brain. HCPEC are cryopreserved after purification and delivered frozen. Each vial contains >5×10^5 cells in 1 ml volume. HCPEC are characterized by immunofluorescent method with antibodies to VWF/Factor VIII, CD31(PCAM) and by uptake of DiI-Ac-LDL. HBMEC are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi. HCPEC are guaranteed to further expand for 15 population doublings in the condition provided by AcceGen Research Laboratories.