TC21/R-Ras2GST Teratocarcinoma oncogene, related ras viral oncogene homolog 2 human, recombinant, E. coli

Ras proteins are members of the superfamily of small GTP-binding proteins that function as molecular switches controlling a variety of signaling and transport pathways. The Ras family of GTP-binding proteins consists of the classical Ras (Ha-, K-, and N-), R-Ras, Rap1, Rap2, Ral, Rheb, Rin, Rit, TC21/R-Ras2, and M-Ras/R-Ras3 (M-Ras). TC21 is a Ras-like GTPase with high oncogenic potential that is found mutated in some human tumors and overexpressed in breast cancer cell lines. TC21 binds physically to c-Raf-1 in a GTP-dependent manner. The GST-Tag facilitates the protein’s application in typical GST pull-down assays.