Cdc42 ΔCGST Cell Division Cycle Protein 42, C-terminal deletion of 13 residues human, recombinant, E. coli

Rho family GTPases Rac1 and Cdc42 (cell division cycle 42) belong to the Ras superfamily of small GTP-binding proteins. The human homolog of yeast Cdc42 is essential for cell polarity and regulates cytoskeletal rearrangements in responses to growth factor stimulation. The C-terminal deletion of 13 amino acids of Cdc42 ΔC includes the polybasic domain consisting of six contiguous basic amino acids. The polybasic domain of Cdc42 is required for homodimer formation.The GST-Tag facilitates the protein`s application in typical GST pull-down assays. Protein preparation is 100% GDP-loaded, measured by HPLC.