KRasHis - G-domain Kirsten rat sarcoma viral oncogene homolog, G-domain human, recombinant, E. coli

Ras proteins are members of the superfamily of small GTP-binding proteins that function as molecular switches controlling a variety of signalling and transport pathways. KRAS gene performs an essential function in normal tissue signaling, and the mutation of a KRAS gene is an essential step in the development of many cancers. KRAS is usually tethered to cell membranes because of the presence of an isoprenyl group on its C-terminus. Protein preparation is 100 % GDP-loaded, measured by HPLC. Human K-Ras is a truncated protein containing amino acids 1-163. The 6His-tag is located at the N-terminus.