H-Ras ΔC (S17N) Harvey rat sarcoma viral oncogene homolog, residues 1-166 human, recombinant, E. coli

Ras proteins are members of the superfamily of small GTP-binding proteins that function as molecular switches controlling a variety of signaling and transport pathways. H-Ras is one of the classic human Ras proteins (H-, N-, K-Ras4A, and K-Ras4B). H-Ras ΔC (aa 1 - 171) lacks the C-terminus with the CaaX recognition sequence necessary for anchoring Ras into the plasma membrane. The mutation S17N results in a 40-fold increase in the affinity for GTP without affecting its affinity for GDP. Protein preparation is 95% GDP- and 5% GTP-loaded, measured by HPLC.