Palbociclib (isethionate)
Palbociclib (PD 0332991) isethionate is an orally active selective CDK4 and CDK6 inhibitor with IC50 values of 11 and 16 nM, respectively. Palbociclib isethionate has potent anti-proliferative activity and induces cell cycle arrest in cancer cells, which can be used in the research of HR-positive and HER2-negative breast cancer and hepatocellular carcinoma[1][3][4].
Product Specifications
CAS Number
[827022-33-3]
Product Name Alternative
PD 0332991 isethionate
UNSPSC
12352005
Hazard Statement
H301
Target
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Palbociclib-isethionate.html
Concentration
10mM
Purity
99.96
Solubility
DMSO : 10 mg/mL (ultrasonic)
Smiles
CC(C1=C(N2C3CCCC3)N=C(NC4=NC=C(N5CCNCC5)C=C4)N=C1)=C(C(C)=O)C2=O.OCCS(O)(=O)=O
Molecular Formula
C26H35N7O6S
Molecular Weight
573.66
Precautions
H301
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
CDK4; CDK6
Citation 01
Available Sizes
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