Guanosine-3',5'-pentaphosphat
(p)ppGpp (collective for ppGpp and pppGpp) is a nucleotide based second messenger and a key regulator of stringent stress response in many bacteria[1]. During nutritional starvation (p)ppGpp initiates the switch from bacterial growth into survival mode. Growth is arrested as (p)ppGpp binds RNA polymerase (RNAP) leading to repressed transcription rate of stable RNA (rRNA, tRNA). Instead, transcription of genes involved in biosynthesis of amino acids is enhanced, leading to prolonged survival[2].
Product Specifications
Product Name Alternative
(pppGpp)
Synonyms
(pppGpp)
UNSPSC
12352208
UNSPSC Description
Nucleic acids
HS Code
29349990
eClass Number
34160990
eClass Product Group
Nucleinsäure (nicht klassifiziert)
Concentration
(100 mM)
Purity
≥ 85 % (HPLC)
Form
Solution in water
pH
7.5 ±0.5
Color
Colorless to slightly yellow
Autoclavability
false
Smiles
[nH]1c(N)nc2n([C@H]3[C@H](O)[C@@H]([C@H](O3)COP(=O)(O)OP(=O)(OP(=O)(O)O)O)OP(=O)(O)OP(=O)(O)O)cnc2c1=O
Shipping Conditions
Shipped on gel packs
Storage Conditions
Store at -20 °C Short term exposure up to 1 week cumulative to ambient temperature possible.
Storage Temperature
Store at -20 °C
Notes
Short term exposure (up to 1 week cumulative) to ambient temperature possible.
Shelf Life
12 months after date of delivery
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