P53 Activator 13
P53 Activator 13 (compound 11) is a 6mA methyltransferase CamA inhibitor and a p53 activator. p53 Activator 13 intercalates into CamA-bound DNA via the minor groove, causing a conformational shift that moves the catalytic domain away from the DNA and elicits DNA damage response via p53 activation. p53 Activator 13 can be utilized in cancer research[1].
Product Specifications
UNSPSC
12352211
Target
DNA Methyltransferase; MDM-2/p53
Type
Reference compound
Related Pathways
Apoptosis; Epigenetics
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/p53-activator-13.html
Smiles
O=C(NC1=CC(CN2CCN(C)CC2)=CC(NC3=NC(N)=NC(C)=C3)=C1)C4=CC=CC(NC5=CC=NC6=C5C=CC=C6)=C4
Molecular Formula
C33H35N9O
Molecular Weight
573.69
References & Citations
[1]Zhou J, et al. Quinoline-based compounds can inhibit diverse enzymes that act on DNA. Cell Chem Biol. 2024 Oct 14:S2451-9456 (24) 00403-3.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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