Coronarin A
Coronarin A is an orally active natural compound that inhibits mTORC1 and S6K1 to increase IRS1 activity. Coronarin A shows anti-inflammatory activity and can also be used for type 2 diabetes mellitus research[1].
Product Specifications
CAS Number
119188-33-9
UNSPSC
12352005
Target
MTOR; Ribosomal S6 Kinase (RSK)
Type
Natural Products
Related Pathways
MAPK/ERK Pathway; PI3K/Akt/mTOR
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/coronarin-a.html
Purity
98.0
Smiles
C[C@@]1([C@H]2/C=C/C3=COC=C3)[C@@](C(C)(CCC1)C)([H])C[C@H](O)C2=C
Molecular Formula
C20H28O2
Molecular Weight
300.44
References & Citations
[1]Huang SL, et al. Coronarin A modulated hepatic glycogen synthesis and gluconeogenesis via inhibiting mTORC1/S6K1 signaling and ameliorated glucose homeostasis of diabetic mice. Acta Pharmacol Sin. 2022 Sep 9.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
MTORC1
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