Coronarin A

Coronarin A is an orally active natural compound that inhibits mTORC1 and S6K1 to increase IRS1 activity. Coronarin A shows anti-inflammatory activity and can also be used for type 2 diabetes mellitus research[1].

Product Specifications

CAS Number

[119188-33-9]

UNSPSC

12352005

Target

MTOR; Ribosomal S6 Kinase (RSK)

Type

Natural Products

Related Pathways

MAPK/ERK Pathway; PI3K/Akt/mTOR

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/coronarin-a.html

Purity

98.0

Smiles

C[C@@]1([C@H]2/C=C/C3=COC=C3)[C@@](C(C)(CCC1)C)([H])C[C@H](O)C2=C

Molecular Formula

C20H28O2

Molecular Weight

300.44

References & Citations

[1]Huang SL, et al. Coronarin A modulated hepatic glycogen synthesis and gluconeogenesis via inhibiting mTORC1/S6K1 signaling and ameliorated glucose homeostasis of diabetic mice. Acta Pharmacol Sin. 2022 Sep 9.