Anti-Cytokeratin 19

Encoded by the KRT19 gene, Cytokeratin 19 along with other members of the keratin family is responsible for the structural integrity of epithelial cells and the organization of myofibers. It is also involved in linking the contractile apparatus to dystrophin at the costameres of striated muscles. Lung cancer and thyroid cancer are the diseases associated with mutations in the KRT19. The Anti-Cytokeratin 19 Antibody also reacts with a wide variety of simple epithelia and non-squamous stratified epithelia. It does not react with stratified squamous epithelia. However, cervical squamous cell carcinomas show positivity with this antibody.