Anti-Cyclin D1
The DMITF1 encodes a transcription factor that contains a cyclin-D binding domain. Expression of this gene is frequently reduced in 40% of human non-small-cell lung carcinomas due to hemizygous gene deletion, strongly suggesting that this locus is haploinsufficient for tumor suppression. The Cyclin D1 is induced by the oncogenic Ras signalling pathway and functions as a tumor suppressor by activating the transcription of ARF to arrest cell growth or induce apoptosis. Other diseases related with the DMITF1 gene include parathyroid adenomas and mantle-cell lymphoma (MCL). The Anti-Cyclin D1 Antibody is a useful tool in cancer research particularly in studying oncogenesis.
Product Specifications
CAS Number
9007-83-4
Reactivity
Human
Immunogen
Recombinant protein corresponding to human Cyclin D1
Clonality
Monoclonal
Type
Antibodies-Monoclonal
Applications
WB,IHC,IP
Concentration
100µg/100µl
Purity
The antibody was affinity-purified from hybridoma supernatant by affinity-chromatography.
Buffer
PBS, pH 7.4 with 0.05% sodium azide
Shipping Conditions
Ice Pack
Storage Conditions
Fragment
IgG2a
Specificity
Anti-Cyclin D1 Antibody recognizes human Cyclin D1
Applications Notes
WB: 1:10000~1:50000; IP: 1:30; IHC: 1:100~1:500. Optimal dilutions should be calculated by the end user based on their specific application.
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