Anti-Collagen Type IV
The type IV collagen is encoded by the two genes, COL4A1 and COL4A2. It is the major structural component of basement membranes along with laminins and enactins. It is able to form insoluble fibres with high tensile strength. The Anti-Collagen Type IV Antibody can recognize type IV collagen in basement membranes in kidney, placenta, lung, skin, and cornea; but it is unable to recognize denatured type IV collagen. The antibody is useful in detecting extracellular matrix proteins as well as the loss of parts of basement membrane in carcinomas.
Product Specifications
Reactivity
Human,Rat
Immunogen
Purified Collagen Type IV extracted from human placenta
Clonality
Monoclonal
Type
Antibodies-Monoclonal
Applications
WB,IHC,ELISA
Concentration
100µg/100µl
Purity
The antibody was affinity-purified from hybridoma supernatant by affinity-chromatography.
Buffer
PBS, pH 7.4 with 0.05% sodium azide
Shipping Conditions
Ice Pack
Storage Conditions
Fragment
IgG1, kappa light chain
Specificity
Human collagen type IV; does not recognize denatured type IV collagen.
Applications Notes
WB: 1:1000~1:10000 ELISA: 1:5000~1:50000 IHC: 1:50~1:500 Optimal dilutions should be calculated by the end user based on their specific application.
CAS Number
9007-83-4
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