Anti-CD45 LCA

Encoded by the gene PTPRC, CD45 is a member of the protein tyrosine phosphatase (PTP) family. It is required for T-cell activation through the antigen receptor. It serves as a positive regulator of T-cell co-activation upon binding to DPP4 and recruits and dephosphorylates SKAP1 and FYN upon T-cell activation. Mutations in the PTPRC gene is associated with diseases including severe combined immunodeficiency (SCID), and hepatitis C. CD45 is useful as a marker to recognize different stem cells such as mesenchymal stem cells and hematopoietic stem cells.

Product Specifications

CAS Number

9007-83-4

Reactivity

Human

Immunogen

Human T lymphocytes

Clonality

Monoclonal

Type

Antibodies-Monoclonal

Applications

WB,IHC,IP

Concentration

100µg/100µl

Purity

The antibody was affinity-purified from hybridoma supernatant by affinity-chromatography.

Buffer

PBS, pH 7.4 with 0.05% sodium azide

Shipping Conditions

Ice Pack

Storage Conditions

This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

Fragment

IgG2a

Specificity

Human CD45 determinant 1

Applications Notes

WB: 1:1000; IP: Use at an assay dependent concentration; IHC: 1:500~1:1000. Optimal dilutions should be calculated by the end user based on their specific application.