Anti-CD117
Encoded by the KIT gene, the CD117 antigen is also known as c-Kit and stem cell factor receptor (SCFR). The CD117 antigen is expressed primarily on hematopoietic progenitor cells, mast cells and neural crest-derived melanocytes. CD117 is a type I transmembrane glycoprotein in the receptor tyrosine kinase (RTK) family which functions in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenensis, mast cell development, migration and function, and in melanogenesis. Mutations with the KIT gene are associated with diseases such as gastrointestinal stromal tumor and piebaldism.
Product Specifications
CAS Number
9007-83-4
Reactivity
Human
Immunogen
Human erythroleukemia cell line OCIM1
Clonality
Monoclonal
Type
Antibodies-Monoclonal
Applications
Flow cyt
Concentration
100µg/100µl
Purity
The antibody was affinity-purified from hybridoma supernatant by affinity-chromatography.
Buffer
PBS, pH 7.4 with 0.05% sodium azide
Shipping Conditions
Ice Pack
Storage Conditions
Fragment
IgG2a
Specificity
Anti-CD117 Antibody recognizes human CD117.
Applications Notes
Use at an assay dependent concentration.
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