Anti-TYK2 (Phospho-Tyr1054)
This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008]
Product Specifications
Reactivity
Human,Mouse
Immunogen
The antibody was produced against synthesized phosphopeptide derived from human TYK2 around the phosphorylation site of tyrosine 1054 (H-E-YP-Y-R).
Clonality
Polyclonal
Type
Antibodies-Polyclonal
Applications
WB
Concentration
100ug/100ul
Purity
Affinity purified
Buffer
Rabbit IgG in phosphate buffered saline (without Mg<sup>2</sup>+ and Ca</sup>2</sup>+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Shipping Conditions
Ice Pack
Storage Conditions
Fragment
IgG
Specificity
TYK2 (phospho-Tyr1054) antibody detects endogenous levels of TYK2 only when phosphorylated at tyrosine 1054.
Applications Notes
WB: 1:500~1:1000
CAS Number
9007-83-4
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