What is the catalog number for Anti-Shc1 (Phospho-Tyr427)?

The catalog number for Anti-Shc1 (Phospho-Tyr427) is Y011317.

What sizes are available for Anti-Shc1 (Phospho-Tyr427)?

Anti-Shc1 (Phospho-Tyr427) is available in the following size(s): 100 µg.

Is Anti-Shc1 (Phospho-Tyr427) in stock?

Anti-Shc1 (Phospho-Tyr427) is currently made to order / not held in immediate stock. Contact us for lead time.

Anti-Shc1 (Phospho-Tyr427)

This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

Product Specifications

CAS Number

9007-83-4

Reactivity

Human,Mouse,Rat

Immunogen

The antiserum was produced against synthesized phosphopeptide derived from human Shc1 around the phosphorylation site of tyrosine 427 (P-S-YP-V-N).

Clonality

Polyclonal

Type

Antibodies-Polyclonal

Applications

WB,IHC

Concentration

1ug/ul

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed

Buffer

phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Shipping Conditions

Ice Pack

Storage Conditions

This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.