Anti-PTEN (Phospho-Ser380)
This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. [provided by RefSeq, Jul 2008]
Product Specifications
CAS Number
9007-83-4
Reactivity
Human,Mouse,Rat
Immunogen
The antiserum was produced against synthesized phosphopeptide derived from human PTEN around the phosphorylation site of serine 380 (R-Y-SP-D-T).
Clonality
Polyclonal
Type
Antibodies-Polyclonal
Applications
IHC
Concentration
1ug/ul
Purity
Buffer
phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Shipping Conditions
Ice Pack
Storage Conditions
Specificity
PTEN (phospho-Ser380) antibody detects endogenous levels of PTEN only when phosphorylated at serine 380.
Applications Notes
IHC: 1:50~1:100
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