Anti-HDAC4/HDAC5/HDAC9 (phospho-Ser246/259/220)
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. [provided by RefSeq, Jul 2008]
Product Specifications
CAS Number
9007-83-4
Reactivity
Human,Mouse
Immunogen
Clonality
Polyclonal
Type
Antibodies-Polyclonal
Applications
WB,IHC
Concentration
100ug/100ul
Purity
Affinity purified
Buffer
Shipping Conditions
Ice Pack
Storage Conditions
Fragment
IgG
Specificity
HDAC4/HDAC5/HDAC9 (phospho-Ser246/259/220) Antibody detects endogenous levels of HDAC4/HDAC5/HDAC9 only when phosphorylated at serine 246/259/220.
Applications Notes
WB: 1:500~1:1000 IHC:1:50~1:100
Frequently Asked Questions
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