Anti-cdc25C (Phospho-Ser216)
This gene is highly conserved during evolution and it plays a key role in the regulation of cell division. The encoded protein is a tyrosine phosphatase and belongs to the Cdc25 phosphatase family. It directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. It is also thought to suppress p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described, however, the full-length nature of many of them is not known. [provided by RefSeq, Jul 2008]
Product Specifications
Reactivity
Human
Immunogen
The antiserum was produced against synthesized phosphopeptide derived from human cdc25C around the phosphorylation site of serine 216 (S-P-SP-M-P).
Clonality
Polyclonal
Type
Antibodies-Polyclonal
Applications
IHC
Concentration
1ug/ul
Purity
Buffer
phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Shipping Conditions
Ice Pack
Storage Conditions
Specificity
cdc25C (phospho-Ser216) antibody detects endogenous levels of cdc25C only when phosphorylated at serine 216.
Applications Notes
IHC: 1:50~1:100
CAS Number
9007-83-4
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